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  • Title: [Iso Kikuchi syndrome (C.O.I.F. syndrome). A report on 2 cases and a review of 44 cases in the literature (author's transl)].
    Author: Baran R.
    Journal: Ann Dermatol Venereol; 1980 May; 107(5):431-5. PubMed ID: 7224526.
    Abstract:
    Attention was drawn to congenital onychodysplasia of the index fingers (C.O.I.F.) by Iso, and later by Kikuchi who collected several cases. Micronychia, polyonychia, anonychia, hemionychrogryphosis and malalignment are the observed index finger defects. Five classical criteria were given to characterize the C.O.I.F. syndrome: 1 degree congenital, 2 degrees involvement of index fingers, 3 degrees variability in nail appearance, 4 degrees non-familial, non-hereditary, 5 degrees without bone and joint abnormalities. Alternative criteria are suggested for this syndrome. These are: 1 degree congenital, 2 degrees unilateral or bilateral index finger involvement, variability in nail appearance, 4 degrees possible hereditary involvement, 5 degrees frequent associated bone abnormalities.
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