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  • Title: [Suppressive effect of synthetic polypeptide GT on the induction of delayed-type hypersensitivity to a complex GT + methylated bovine serum albumin (author's transl)].
    Author: Drach G, Barbu E.
    Journal: Ann Immunol (Paris); 1980; 131D(3):299-307. PubMed ID: 7224587.
    Abstract:
    Delayed-type hypersensitivity (DTH) to the random copolymers poly(Glu50Tyr50) (GT) or poly(Glu60Ala30Tyr10) (GAT) could be produced in BALB/c mice when the polymers were injected complexed to a methylated bovine serum albumin (mBSA). The pretreatment with GT or with mBSA 4 days before the immunisation with the complex GT-mBSA suppressed the induction of the DTH to both GT and mBSA moieties of the GT-mBSA complex. A similar pretreatment with GAT had no suppressor effect on the induction of DTH to GT-mBSA. Injection of cyclophosphamide 2 days before or 2 days after the pretreatment with GT eliminated the suppressor effect of GT on the induction of DTH with the complex GT-mBSA.
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