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  • Title: Clonidine-induced lipolysis in dog adipocytes by stimulation of histamine (H2)-receptors.
    Author: Berlan M, Lafontan M, Dang Tran L, Carpene C.
    Journal: Arch Int Pharmacodyn Ther; 1981 Feb; 249(2):213-20. PubMed ID: 7224722.
    Abstract:
    The effect of the alpha-adrenergic agonist clonidine on lipolysis was investigated in omental dog fat cells. In presence of theophylline, clonidine markedly enhanced lipolysis. This effect was competitively inhibited by the (H2)-receptor blocking agent cimetidine while the H1-histamine receptor antagonist (mepyramine) was without any significant effect. This result suggests that clonidine stimulates dog adipocyte lipolysis through histamine (H2)-receptor activation. Histamine and clonidine stimulated dog fat cell adenylate cyclase; the stimulation was suppressed by cimetidine.
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