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  • Title: Recurrent pseudomembranous colitis unassociated with prior antibiotic therapy.
    Author: Moskovitz M, Bartlett JG.
    Journal: Arch Intern Med; 1981 Apr; 141(5):663-4. PubMed ID: 7224749.
    Abstract:
    Fulminant and recurring pseudomembranous colitis developed in an elderly woman without prior antibiotic administration within the previous year. Stool culture yielded Clostridium difficile, and tissue cultures showed C difficile cytotoxin. Treatment with vancomycin hydrochloride was initially successful, but a serious relapse after its discontinuation necessitated low-dose long-term prophylaxis. Clostridium difficile may be responsible for pseudomembranous colitis unassociated with antibiotic therapy.
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