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  • Title: Seizures elicited by subcutaneous injection of metrazol during ontogenesis in rats.
    Author: Mares P, Schickerová R.
    Journal: Act Nerv Super (Praha); 1980 Dec; 22(4):264-8. PubMed ID: 7225195.
    Abstract:
    Metrazol administered subcutaneously at a dose of 80 mg . kg-1 elicited genuine minimal seizures (predominantly clonic) in adult, 45- and 25-day-old rats. The same dose of metrazol resulted in long-lasting generalized tonic-clonic seizures in rats aged 15 days and younger. Eighteen-day-old rats represented a transitory stage in which both types of seizures were present: minor seizures at first and then, after a short resting period, major seizures. A different seizure pattern in young rats was not induced by their higher sensitivity to metrazol, but was caused by the level of neural maturation.
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