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  • Title: On the mechanism of hydrogen-deuterium exchange in bacteriorhodopsin.
    Author: Doukas AG, Pande A, Suzuki T, Callender RH, Honig B, Ottolenghi M.
    Journal: Biophys J; 1981 Feb; 33(2):275-9. PubMed ID: 7225508.
    Abstract:
    Continuous-flow resonance Raman experiments carried out in bacteriorhodopsin show that the exchange of a deuteron on the Schiff base with a proton takes place in times shorter than 3 ms. Exchange mechanisms based on a base-catalyzed deprotonation followed by reprotonation of the Schiff base are excluded. A mechanism is suggested in which a water molecule interacts directly with the Schiff base deuteron in a concerted exchange mechanism. It appears that in the dark, the binding site is more accessible to neutral water molecules than to charged protons.
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