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Title: Carcinoma of the colon arising at ureteral implant sites despite early external diversion: pathogenetic and clinical implications. Author: Schipper H, Decter A. Journal: Cancer; 1981 Apr 15; 47(8):2062-5. PubMed ID: 7226098. Abstract: Colon carcinomas develop at the site of implantation in approximately 6% of patients who undergo ureterosigmoidostomy for benign conditions. Generally, the obstruction of a long-functioning ureterosigmoidostomy heralds the presentation of the malignancy. The development of a carcinoma of the colon at the site of the ureteral stump 22 years after conversion to ileal conduit in a ureterosigmoidostomy, which had been in place for only nine months, raises fundamental questions about the pathogenesis of the tumor. The long-assumed role of urine in the induction of these iatrogenic tumors must be questioned. This issue and suggestions for management and prevention are discussed.[Abstract] [Full Text] [Related] [New Search]