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  • Title: Dose response of 1,2-dimethylhydrazine and methylazoxymethanol acetate in the F 344 rat.
    Author: McConnell EE, Wilson RE, Moore JA, Haseman JK.
    Journal: Cancer Lett; 1980 Jan; 8(3):271-8. PubMed ID: 7226147.
    Abstract:
    Weanling male and female F 344 rats were given various doses of 1,2-dimethylhydrazine (DMH) or methylazoxymethyl acetate (MAMAc), and were then held for 46-64 weeks in an effort to determine a dose response and establish a dose level which would produce a low level of intestinal neoplasia with a minimal number of tumors in other organs. DMH proved superior to MAM in this respect, although liver lesions were still observed with both compounds at the lowest carcinogenic intestinal dose.
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