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  • Title: A new warfarin metabolite: structure and function.
    Author: Fasco MJ, Dymerski PP, Wos JD, Kaminsky LS.
    Journal: J Med Chem; 1978 Oct; 21(10):1054-9. PubMed ID: 722713.
    Abstract:
    The metabolism of the clinically utilized, anticoagulant warfarin [4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one] by rat liver microsomes has been investigated. The structure of a new warfarin metabolite [4-hydroxy-3-(3-oxo-1-phenyl-1-butenyl)-2H-1-benzopyran-2-one] (dehydrowarfarin) has been determined by mass spectral comparison with the chemically synthesized compound. The formation of dehydrowarfarin is catalyzed by cytochrome P-450 and is unusual in that the final product is effectively dehydrogenated warfarin.
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