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  • Title: Serum progesterone in women with lactational amenorrhoea.
    Author: Joshi UM, Joseph R, Adatia AR, Choudhary VN, Joshi JV, Mehta S, Hazari KT.
    Journal: Indian J Med Res; 1980 Oct; 72():508-11. PubMed ID: 7228173.
    Abstract:
    A cross-sectional study was conducted to detect the return of ovulation in 56 women with (LA) lactational amenorrhea ranging from 2-12 months. As serum progesterone of 5 ng/ml provides an indirect evidence of ovulation. It was estimated by radioimmunoassay in 4 blood samples collected weekly over a period of 1 month in all the women. 37 women showed persistently low values of progesterone ( 5 mg/ml) throughout the study period. The other 19 women had serum progesterone of 5 ng/ml in 1 or several samples. 13 of these women, however, continued to have LA beyond 1 month in spite of the detection of high circulating progesterone. The possibility of pregnancy was excluded in all of them. The endometrial refractoriness to the circulating steriods is proposed as a mechanism of persistent LA.
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