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  • Title: Acrylonitrile-14C metabolism in rats: effect of the route of administration on the elimination of thiocyanate and other radioactive metabolites in urine and feces.
    Author: Gut I, Kopecký J, Filip J.
    Journal: J Hyg Epidemiol Microbiol Immunol; 1981; 25(1):12-6. PubMed ID: 7229351.
    Abstract:
    In Wistar rats, the elimination of the sum of radioactive metabolites of acrylonitrile--14C was not markedly influenced by the rote of acrylonitrile administration. The elimination of thiocyanate, however, was significantly higher after oral (23% of the dose) than after intraperitoneal (4%), subcutaneous (4.6%), or intravenous (1.2%) administration. The elimination of the sum of radioactive metabolites was highest in the first 4 hours after acrylonitrile administration and rapidly decreased, whereas the excretion of thiocyanate reached maximum between hour 8 and 14 after oral or intraperitoneal administration. Less than 1% of radioactivity of the acrylonitrile--14C dose was eliminated in feces irrespective of the route of administration.
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