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  • Title: Selenium-sulfur analogs III: synthesis and biodistribution of two 75Se-labeled 4-substituted-1,2,3-selenadiazoles.
    Author: Hanson RN, Davis MA.
    Journal: J Pharm Sci; 1981 Jan; 70(1):91-3. PubMed ID: 7229937.
    Abstract:
    The 75Se-labeled 4-substituted-1,2,3-selenadiazole analogs of two drugs that inhibit the adrenocorticosteroid 11 beta- and 17 alpha-hydroxylase enzymes were prepared by the [75Se]selenious acid oxidation of the appropriate methyl ketone semicarbazones. The concentration of the radiolabeled compounds in the adrenal glands of rats over a 0.25--24-hr period was determined and compared with that in the blood, liver, and kidneys. The concentration in the adrenal glands and the target to nontarget ratios were much lower than those reported for other adrenocorticosteroid inhibitors. Therefore, these 1,2,3-selenadiazole agents do not have potential as adrenocorticosteroid imaging agents.
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