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  • Title: Voltage-clamp investigations of membrane currents underlying pace-maker activity in rabbit sino-atrial node.
    Author: Brown H, Difrancesco D.
    Journal: J Physiol; 1980 Nov; 308():331-51. PubMed ID: 7230019.
    Abstract:
    1. Small preparations of spontaneously beating rabbit sino-atrial node have been investigated using the two micro-electrode voltage-clamp technique. 2. Hyperpolarizing clamp pulses given from holding potentials of about -45 mV reveal a time-dependent change of a membrane current, if, which is shown to overlap the pace-maker range (-65 mV to -45 mV) for these preparations. 3. The changes in if are shown to be quite distinct from the de-activation of the time-dependent outward current, iK. 4. The time-dependent changes of the if system increase during adrenaline application and therefore contribute to the chronotropic action of adrenaline on the heart. 5. Evidence for a link between slow inward current (iSi) and time-dependent outward current (iK) in rabbit sino-atrial node is presented and assessed.
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