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  • Title: Some novel pyrazolone derivatives as anti-inflammatory agents.
    Author: Farghaly AM, El-Khwass SM, Khalil MA, Sharabi FM, Daabees TT.
    Journal: Pharmazie; 1981; 36(2):93-5. PubMed ID: 7232494.
    Abstract:
    Synthesis of three series of compounds namely; 4-(phenazon-4-ylazo)-1-substituted thiocarbamoyl-3-methyl-5-pyrazolones (3-8), 4-(phenazon-4-ylazo)-1-substituted-3-methyl-5-pyrazolones (9-20) and 4-(phenazon-4-ylazo)-1-substituted-3,5-dimethylpyrazoles (21-31) was achieved. These compounds were subjected to anti-inflammatory investigation and it was found that compounds 9 and 10 exhibited a remarkable anti-inflammatory activity, of which the former was the most potent.
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