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  • Title: [Studies on the mechanism and the significance of prostaglandin biosynthesis by the ovary--conversion of 14C-arachidonic acid to prostaglandins (author's transl)].
    Author: Mitsuhashi N.
    Journal: Acta Obstet Gynaecol Jpn; 1981 May; 33(5):591-6. PubMed ID: 7234347.
    Abstract:
    Biosynthesis of prostaglandins (PGs) from 14C-arachidonic acid was studied using homogenates of the ovaries from rats, gilts and human. Among the radioactive metabolites extracted, PGE2 and 6 keto PGF1 alpha were purified and identified by silicic acid column-, thin layers-, reversed phase partition chromatographies, and radiogaschromatography. Treatment with PMS-hCG activated metabolism of arachidonic acid into radioactive metabolites including PGE2 and 6 keto PGF1 alpha to a large extent. Therefore it is concluded that LH or (hCG) activate the PG synthetase system through the induction of synthetase itself and/or a stimulatory factor.
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