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  • Title: Sterol-polyene antibiotic complexation: probe of membrane structure.
    Author: Bittman R.
    Journal: Lipids; 1978 Oct; 13(10):686-91. PubMed ID: 723481.
    Abstract:
    Polyene antibiotics are useful tools for studying the role of sterols in biological membranes. The interaction of polyene antibiotics with membrane-bound sterols in artificial membrane systems, prokaryotic and eukaryotic cells, and lipid-containing viruses is reviewed. The pentaene macrolide, filipin, is shown to serve as a probe of phosphatidylcholine-sterol interaction and of the localization of cholesterol in the membrane of mycoplasmas.
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