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  • Title: Analysis of the variability in cleavage times and demonstration of a mitotic gradient during the cleavage stages of Nothobranchius guentheri.
    Author: Van Haarlem R, Van Wijk R, Fikkert AH.
    Journal: Cell Tissue Kinet; 1981 May; 14(3):285-300. PubMed ID: 7237515.
    Abstract:
    Living embryos of the annual cyprinodont fish Nothobranchius guentheri were observed under the microscope. Detailed records were made of the time of cell division, disappearance of the nucleus and of the position of each cell within the blastoderm up to and includig the sixth cleavage. Combination of these data revealed the presence of a mitotic gradient, a cell division gradient and a gradient of cell cycle duration in the 8-cell, 16-cell and 32-cell stage. Comparison of the variabilities in the duration of the interphase and mitosis reveals that differences between sister cell intercleavage times in the 8-, 16- and 32-cell stage are, for the most part, due to the variability in the duration of the mitotic process. It is concluded that the DNA-division cycle is composed of at least two parallel series of events. We found the random transition model of cell cycle control, originally based on the analysis of intermitotic times of mammalian cells in tissue culture, helpful also in analysing intercleavage time variability in embryonic cells.
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