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  • Title: Effects of glucocorticoids on hormone-stimulated lipolysis and calcium uptake in the adipose cells.
    Author: Kawai A, Kuzuya N.
    Journal: Horm Metab Res; 1981 Apr; 13(4):224-8. PubMed ID: 7239436.
    Abstract:
    Hormone-induced lipolysis and calcium accumulation were concomitantly reduced in the adipose tissue from adrenalectomized rats. In contrast, both epinephrine-activated lipolysis and calcium accumulation were potentiated when the adipocytes were preincubated with 33 ng/ml of dexamethasone for 3 hrs. These potentiating effects of dexamethasone on epinephrine-stimulated lipolysis were completely inhibited when the adipocytes were preincubated with the steroid and verapamil which inhibited hormone-induced calcium influx into the adipocytes. These findings suggest that the potentiating effect of glucocorticoid on hormone-stimulated lipolysis depends upon its accelerating action on hormone-induced calcium influx into the adipocytes.
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