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  • Title: Combined carcinogenic action of chrysotile asbestos dust and N-nitrosodiethylamine on the respiratory tract of Syrian golden hamsters.
    Author: Küng-Vösamäe A, Vinkmann F.
    Journal: IARC Sci Publ; 1980; (30):305-10. PubMed ID: 7239649.
    Abstract:
    The combined carcinogenic activity of intratracheally inoculated Canadian chrysotile asbestos dust and orally or subcutaneously administered NDEA has been studied in long-term experiments in Syrian golden hamsters. In animals treated with asbestos only, no lung tumours developed, and single tracheal or laryngeal papillomas were found in only a very few cases. In animals treated with asbestos and NDEA, a synergistic effect which increased the incidence of lung tumours was observed.
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