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  • Title: Inhibitory action of calcium antagonists on ATP-dependent calcium uptake by the renal cortical microsomes.
    Author: Dan T, Gemba M.
    Journal: Jpn J Pharmacol; 1980 Dec; 30(6):913-7. PubMed ID: 7241862.
    Abstract:
    Effects of Ca2+ antagonists, verapamil and diltiazem, on uptake and release of Ca2+ by microsomes of the renal cortex were studied. Verapamil inhibited the ATP-dependent Ca2+ uptake by renal microsomes. Addition of 0.8 mM verapamil was required to produce 50% inhibition of the ATP-dependent CA2+ uptake. Diltiazem also depressed the Ca2+ uptake was not due to an increased permeability for Ca2+, since release of Ca2+ from the microsomes was not significantly affected by either drug. It is proposed that verapamil and diltiazem inhibit Ca2+ transport by interfering with an active process of Ca2+ accumulation in microsomes of the renal cortex.
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