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  • Title: Thiamine protection of murine L1210 leukemia cells against mechlorethamine cytotoxicity and its relation to the choline uptake system.
    Author: Naujokaitis SA.
    Journal: Res Commun Chem Pathol Pharmacol; 1981 May; 32(2):317-27. PubMed ID: 7244366.
    Abstract:
    Thiamine is an inhibitor of choline transport by murine L1210 leukemia cells and a protector of these cells from growth inhibition by mechlorethamine in vitro. Combination chemotherapy of tumor bearing mice with thiamine and mechlorethamine increased the mechlorethamine dosage required for a 50 to 60 percent increase in survival time but did not improve survival over that obtained with mechlorethamine alone.
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