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  • Title: Carcinogenicity in mice of mutagenic compounds from a tryptophan pyrolyzate.
    Author: Matsukura N, Kawachi T, Morino K, Ohgaki H, Sugimura T, Takayama S.
    Journal: Science; 1981 Jul 17; 213(4505):346-7. PubMed ID: 7244619.
    Abstract:
    The compounds 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole and 3-amino-1-methyl-5H-pyrido[4,3-b]indole, which are potent mutagens in a tryptophan pyrolyzate, ar hepatic carcinogens when given orally to mice at concentrations of 200 parts per million in a pellet diet. Female mice showed higher susceptibilities to both compounds than male mice.
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