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  • Title: The effect of controlled daily blood loss on the haemoglobin concentration, erythrocyte count and reticulocyte count of male rats.
    Author: Capel-Edwards K, Wheeldon JM, Mifsud CV.
    Journal: Toxicol Lett; 1981 Apr; 8(1-2):29-32. PubMed ID: 7245238.
    Abstract:
    0.2, 0.6 or 1 ml of blood was removed from rats once daily on 17 consecutive days. Haemoglobin concentration and erythrocyte counts fell rapidly until day 7 or 9 and were reflected after day 2 by an increase in reticulocytes. From 9 to 17 there was little further change and 14 days after the last bleed the haematological results were within the normal range. The increase in haemoglobin production correlated well with the increase in reticulocyte numbers.
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