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  • Title: [Effect of amino acid imbalance and ascorbic acid deficit on the carcinogenic effect of N-nitrosopiperidine].
    Author: Sharmanov TSh, Aĭdzhanov MM, Kolycheva NI.
    Journal: Vopr Pitan; 1981; (2):5-10. PubMed ID: 7245695.
    Abstract:
    A study was made of the effect of ascorbic acid deficiency and low levels of lysine, methionine and threonine on the cancerogenic effect of nitrosopiperidine which was fed to guinea-pigs with drinking water in a single dose of 4.25 mg/kg bw. Deficiency of the nutrients given alone or especially in combination speeded up the growth tumors induced by the cancerogenic agent. A possibility of inducing esophageal tumors in guinea-pigs has been demonstrated for the first time.
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