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  • Title: Induction and development of mouse liver glutathione S-transferase activity.
    Author: Shoemaker DD, Dietrick DD, Cysyk RL.
    Journal: Experientia; 1981 May 15; 37(5):445-6. PubMed ID: 7250306.
    Abstract:
    Mouse liver glutathione S-transferase activity at birth was 1/10 that of adults, and increased steadily with each successive week of age until adult values were reached at 8 weeks. Activity was inducible with phenobarbital; however, the percentage increase in activity was dependent upon substrate. 2 distinct peaks of transferase activity were obtained on CM-cellulose chromatography. The ratios of transferase activity observed for each peak demonstrated that glutathione S-transferase activity in mouse liver is associated with at least 2 distinct proteins with differing substrate specificities.
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