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  • Title: [Influence of one-time aflatoxin intoxication on lysosomes and ultrastructure of liver cells].
    Author: Krustev LP, Kamenova BB.
    Journal: Gegenbaurs Morphol Jahrb; 1981; 127(1):12-9. PubMed ID: 7250649.
    Abstract:
    White male Wistar rats were treated with 6 and 10 mg/kg of Aflatoxin Bi intraperitoneally. 3 h afterwards, they were decapitated and their livers processed after the classical histological methods for electron microscopy as well as after the method of Gomory-Holt for acid phosphatase in liver tissue. The ultrastructural changes affected the nucleus and its chromatin; the rough and smooth endoplasmic reticulum were vacuolised; the Golgi apparatus was activated; the autophagic function of the hepatocyte lysosomes was underlined, as well as the heterophagic in the Kupffer cells. The findings are discussed as signs of early degenerative process, or of lipophanerosis.
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