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  • Title: Red blood cell preservation in protein-poor media. 2. Studies of changes in red cell shape during storage.
    Author: Högman CF, Arro E, Hedlund K.
    Journal: Haematologia (Budap); 1980; 13(1-4):135-44. PubMed ID: 7250809.
    Abstract:
    Red cells stored for up to 35 days have been studied by scanning electron microscopy. Formation of spicules occurred under all storage conditions in CPD and CPD-adenine whole blood, CPD-adenine red cell concentrate, and saline-adenine-glucose red cell concentrate. The number of cells with normal or near normal shape was larger if the blood was stored as a moderately concentrated suspension in saline-adenine-glucose medium or in autologous plasma as compared to the storage as whole blood. The occurrence of echinocytes during storage at +4 degrees C was not correlated to red cell ATP. It was shown that a drastic reduction of ATP leads to an increased formation of both spherocytes and echinocytes. The change of red cell shape during storage at +4 degrees C thus can be due to two processes, one unrelated to ATP and another related to ATP. Why storage as red cell concentrate is superior is not fully understood.
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