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  • Title: High-performance liquid chromatographic determination of trithiozine and its neutral metabolites in human plasma and urine.
    Author: Crolla T, Borsa M, Pifferi G.
    Journal: J Chromatogr; 1981 Feb 13; 222(2):257-63. PubMed ID: 7251743.
    Abstract:
    A high-performance liquid chromatographic method for the quantitation of the new anti-secretory and antiulcer drug trithiozine in human plasma and urine is reported. The procedure is simple and precise; it allows the simultaneous determination of therapeutic doses of the drug and its three main metabolites, namely, 4-(3,4,5-trimethoxythiobenzoyl)tetrahydro-1,4-oxazine S-oxide, 4-(3,4,5-trimethoxybenzoyl)tetrahydro-1,4-oxazine, and 2-hydroxy-4-(3,4,5-trimethoxybenzoyl)tetrahydro-1,4-oxazine.
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