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  • Title: Simultaneous determination of phencyclidine and monohydroxylated metabolites in urine of man by gas chromatography-mass fragmentography with methane chemical ionization.
    Author: Cone EJ, Buchwald W, Yousefnejad D.
    Journal: J Chromatogr; 1981 May 08; 223(2):331-9. PubMed ID: 7251787.
    Abstract:
    Phencyclidine and monohydroxy metabolites were measured in human urine using gas chromatography-mass fragmentography with methane chemical ionization. Samples were extracted either untreated or following acid hydrolysis, derivatized with heptafluorobutyric anhydride, separated on a 3% SE-30 column and analyzed by mass fragmentography. The assay was sensitive to ca. 0.01 microgram/ml for phencyclidine and ca. 0.05 microgram/ml for the metabolites. Urine samples from five human subjects enrolled in a methadone maintenance program who had ingested phencyclidine were analyzed. The phencyclidine concentration ranged from 0.3 to 23.7 microgram/ml. The concentrations of metabolites ranged from 0 to 1.8 microgram/ml. A new monohydroxy metabolite was detected in the samples, but its structure was not fully elucidated. The specificity of the assay was examined.
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