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Title: The use of technetium-99m sulfur colloid as a marker for experimental venous thrombosis: concise communication. Author: Bardfeld PA, Rand J, Goldsmith SJ. Journal: J Nucl Med; 1981 Jul; 22(7):598-600. PubMed ID: 7252564. Abstract: The binding of technetium-99m sulfur colloid to in vivo thrombi was studied in a rat model of deep vein thrombosis. After thrombosis was induced by mechanical traumatization of a right femoral vein segment, technetium-99m sulfur colloid was injected into the peripheral veins of different experimental groups at intervals of 30 min and 1-7 days. Ratios of mean activity in traumatized right femoral vein segment to activity in control segments of left femoral vein (R/L ratios) ranged form 2.97-11.0 for all in situ venous thrombi studied. There was no relation between clot size and R/L ratios. The significant uptake ratios observed by us for venous thrombi up to 1 wk in age suggest that in vivo thrombus detection may be feasible by imaging with a gamma camera after technetium-99m sulfur colloid injection in a peripheral vein.[Abstract] [Full Text] [Related] [New Search]