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  • Title: Sister chromatid exchange in aged human lymphocytes. A brief note.
    Author: Schmidt MA, Sanger WG.
    Journal: Mech Ageing Dev; 1981 May; 16(1):67-70. PubMed ID: 7253721.
    Abstract:
    A study of the sister chromatid exchange (SCE) frequency in peripheral lymphocytes from 26 human subjects, with in vivo age of the cells as the variable, demonstrated a significant increase in SCE frequency with increasing age of the subject (analysis of variance: p less than 0.01). The cells were cultured in Eagles' basal medium with 5-bromodeoxyuridine added to a final concentration of 10 microM. These results are contradictive to the brunt of the literature which indicates that background SCE frequency does not change with age.
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