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  • Title: Induction of 8-azaguanine resistance and sister chromatid exchange in human lymphocytes exposed to mitomycin C and X rays in vitro.
    Author: Evans HJ, Vijayalaxmi.
    Journal: Nature; 1981 Aug 13; 292(5824):601-5. PubMed ID: 7254356.
    Abstract:
    Indirect evidence implies that 8-azaguanine-resistant (AGr) lymphocytes in human peripheral blood are mutants associated with the loss of the hypoxanthine-guanine phosphoribosyltransferase (HPRT) locus on the active X chromosome, the mutation frequency increasing linearly with age. AGr variants are readily induced in lymphocytes exposed to mitomycin C in vitro, their incidence correlating with induced sister chromatid exchanges (SCEs). Although SCE events and the development of an AGr phenotype may reflect a common type of DNA damage, mitomycin C-induced Agr variants are not mutants but are suggested to be cells having a transcriptional block at the HPRT locus. AGr variants are also readily induced by X rays in vitro, their incidence correlates closely with the incidence of aberrations induced in the X chromosome and they are considered to have a mutational origin.
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