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  • Title: [Abortion in the 2d trimester by extra-amniotic infusion. Description of 149 cases].
    Author: Blum M.
    Journal: Minerva Ginecol; 1981; 33(2-3):253-6. PubMed ID: 7254656.
    Abstract:
    Abortion was induced in 149 women through extraamniotic administration of saline solution; 127 women had a regular pregnancy and were between 15-24 weeks of gestation, and 22 had a missed abortion and were between 12-38 weeks of gestation. Age was between 15-42 and parity 1-9. Rhythm of infusion was 16-18 drops of solution per minute; oxytocin was administered intravenously only in those cases in which uterine contractions were poor. Infusion to abortion interval was 5-72 hours of women with regular pregnancy, and 5-28 hours for women with missed abortion; 62.99% of patients with regular pregnancy aborted within the first 24 hours. Only 1.57% of women with regular pregnancy did not need oxytocin, versus 31.8% of women with missed abortion. There were no complications, and only 1 case of fever. None of the methods used for second trimester abortion is ideal; mortality rate is reputed to be about 15.3/1000.000 abortions, and delivery rate about 14.8/100.000 live births. The method presented in this article may be used in cases where other methods may be dangerous; it is without side effects, it is safe and cheap. Moreover, it is much faster than either intraamniotic saline solution, prostaglandins infusion or urea infusion. The mechanism of action of this method is still under investigation, but it is probable that saline isotonic solution provokes prostaglandins secretion, which, in turn, provokes uterine contractions.
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