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Title: Effects of the number of DNP groups on dinitrophenylated human serum albumin upon the induction of immunological memory for the dinitrophenyl determinant. Author: Larralde C, Lagunoff D. Journal: Arch Invest Med (Mex); 1977; 8(3):165-74. PubMed ID: 72549. Abstract: Immunological memory to the DNP determinant is shown to be a positive correlate of the primary anti-DNP response and of the extent of DNP substitution in the priming antigen. Antigen dose-response curves for immunological memory first increase with antigen dose to reach a maximum and then decrease in the high dose region. Increasing the extent of DNP substitution in the priming antigen shifts the dose-response curves to lower antigen doses and promotes the antigen's ability to induce immunological memory to a level greater than that expected by its ability to induce a primary response. The findings are interpreted in terms of postulated effects of degree of DNP substitution on the binding of antigen to cell receptors.[Abstract] [Full Text] [Related] [New Search]