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  • Title: [Redifferentiation and a karyotypic structural change in populations of tumorous rhabdomyoblasts proliferating in the anterior chamber of the eye].
    Author: Al-Rubay AK, Grigor'eva EG, Mosevich TN, Shvemberger IN.
    Journal: Tsitologiia; 1981 Jun; 23(6):647-53. PubMed ID: 7256861.
    Abstract:
    A study was made of the transplantable rhabdomyosarcoma of mice M-62 during its transplantation after 15 passages simultaneously into the subcutaneous connective tissue and the eye anterior chamber (EAC), the latter being an immunologically advantageous site. The transplantable rhabdomyosarcoma cell populations, proliferating in EAC, are characterized by a higher differentiation level as compared with those proliferating in the subcutaneous connective tissue, the cells being taken from the same tumour, at the same passage. Morphologically it is expressed in the appearance of cytotypical (myofibrils in mononuclear tumour myoblasts) and histotypical (formation of myosymplasts) characters of differentiation. The increase in the intensity of differentiation correlates with changes in the ratios of M- and H-forms of LDH towards that which is characteristic of the definitive skeletal muscle tissue. A more intensive differentiation occurs on the background of changes in the karyotype structure of the populations of tumour myoblasts expressed in the increased share of diploid cells. An assumptions is made that the populations of tumour cells proliferating in EAC, i. e. under conditions of isolation from the immunological reactions of the organism, demonstrate changes towards normalization.
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