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  • Title: [AMP-aminohydrolase activity and its regulation in subcellular fractions of white rat brains during aging].
    Author: Mkrtchian GA, Aprikian GV, Paronian ZhA.
    Journal: Zh Evol Biokhim Fiziol; 1981; 17(2):176-81. PubMed ID: 7257665.
    Abstract:
    Studies have been made on deamination of AMP in homogenates, crude and purified mitochondrial, as well as in synaptosomal fractions of the brain in rats. It was shown that in senile animals deamination of AMP in the absence of activator in homogenates and purified mitochondrial fraction is decreased, remaining unchanged in crude mitochondrial and synaptosomal fractions. When stimulated by ATP, the intensity of deamination in senile rats is lower than in all the fractions investigated excluding synaptosomal one. It is concluded that deamination of adenine nucleotides does not play any role in accumulation of preformed ammonia in senile animals.
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