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  • Title: Transient apnea after an enkephalin analogue in the preterm rabbit.
    Author: Hedner T, Hedner J, Bergman B, Lundberg D.
    Journal: Biol Neonate; 1981; 39(5-6):290-4. PubMed ID: 7260213.
    Abstract:
    FK 33-824, a potent enkephalin analogue was administered systemically, 0.5-5 mg/kg to preterm neonatal rabbits. A marked decrease in respiratory frequency as well as irregular breathing and apneic spells was recorded at 5 mg/kg. Tidal volume was not affected. The enkephalin-induced respiratory depression was restored immediately after naloxone (10 mg/kg). Bases on the results it may be speculated upon whether brain stem enkephalin neurons are involved in the pathogenesis of neonatal transient apnea and irregular breathing.
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