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  • Title: [Metabolism of homocarnosine and gamma-amino butyric acid in different regions of rat brain under hyperoxia].
    Author: Bondarenko TI, Krichevskaia AA, Shugaleĭ VS.
    Journal: Ukr Biokhim Zh (1978); 1978; 50(5):573-5. PubMed ID: 726092.
    Abstract:
    The content of homocarnosine, GAMA, histidine, glutaminic acid and activity of glutamate decarboxylase were studied in four regions of rats brain: cerebral hemispheres, midbrain, diencephalon and cerebellum, in norm and under hyperoxia. A considerable decrease in the content of homocarnosine, GAMA and histidine is observed in all the studied regions of the rat brain in the convulsion stage of oxygen poisoning. A decrease in the glutamate decarboxylase activity is the reason for a drop in the GAMA content. Homocarnosine in the brain is bound functionally with the GAMA level.
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