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  • Title: Retrospective study in 430 patients with Hodgkin's disease (1965-1974).
    Author: Zámecník J, Kubec V, Cerná T, Dienstbier Z, Foltýnová V, Masopust J, Reźný Z, Mostecký H, Kirschnerová Z, Bednár B.
    Journal: Czech Med; 1981; 4(1-2):1-9. PubMed ID: 7261806.
    Abstract:
    The authors from 11 institutions in the Czech Socialist Republic, grouped into a Complex Rationalisation Brigade for the diagnosis and therapy of the malignant lymphogranuloma, present results of a retrospective study in 430 patients with Hodgkin's disease. The results were obtained after the data treatment on a digital computer and concern with a general characteristic of the group of patients, that involved 57,2% men and 42,8% women with a peak of the age distribution between 20 and 30 years and a second peak between 60 and 70 years. In the clinical data there is an analysis of the rate of occurring the lesion in particular groups of nodes, where the nodes of mediastinum and of the neck were involved most frequently. In the therapeutic procedures the radiotherapy, cytostatic therapy and their combination are evaluated. The 5-year survival in the whole group is of 41%. Out of this, in the first five years of the period of interest and in the second five years, the numbers of the surviving patients were of 33 and 47% respectively. In the Tables, there are complete remissions, mean times of the remission and longest time of the remission for different methods of the therapy. When evaluating the relapse of the disease, it was possible to observe not only the dependence on the total time of irradiation but also on the time distribution of the dose. The patients with involved nodes above the diaphragm have a better prognosis than those with lesions of nodes in the subdiaphragm region.
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