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  • Title: Histogenesis of microscopic adenoma and hyperplastic (metaplastic) gland in nonpolyposis coli.
    Author: Oohara T, Ogino A, Tohma H.
    Journal: Dis Colon Rectum; 1981; 24(5):375-84. PubMed ID: 7261822.
    Abstract:
    Histogenesis of microscopic adenoma in nonpolypoid colons (those not included in the special disease group of familial polyposis coli) was investigated using complete serial sections with the following results: Adenoma arises from basal cells in the deep layer of the mucosa; and two types of basal cells found were 1) those which had already undergone changes to adenoma and 2) those which are in their transitional stage to adenomas. Early-phase growth of adenoma is brought about by branching. Individual hyperplastic (metaplastic) glands constituting so-called hyperplastic (metaplastic) polyps are considered to be only an expression of one variant in the growing process of adenomas and the glands showing these changes most characteristically have a serrated pattern. Based on these findings, the histogenesis of adenoma in nonpolypoid colons is shown schematically.
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