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  • Title: In vivo effect of 13 Leu motilin on the electric activity of the rabbit sphincter of Oddi.
    Author: Sarles JC, Delecourt P, Devaux MA, Amoros JP, Guicheney JC, Wünsch E.
    Journal: Horm Metab Res; 1981 Jun; 13(6):340-2. PubMed ID: 7262836.
    Abstract:
    Myoelectrical activity of the sphincter of Oddi was studied in 15 anaesthetized and laparotomized male rabbits, before and after injection of various doses of 13 Leucine Motilin (13 L Motilin), a biological and structural analogue of natural motilin. It can be concluded that 13 L Motilin provoked an increase of the sphincter of Oddi spike activity with doses ranging from 0.1 to 1.6 x 10(-6) g/kg. This effect had begun one minute after the injection, reached its maximum at the second minute and lasted for fifteen minutes. The action of 13 L Motilin is dose-related between 0.2 and 0.6 x 10(-6).
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