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  • Title: Amyloidosis in (CBA/J X A/J)F2 mice: correlation of amyloid resistance and low mitogenic response to concanavalin A.
    Author: Wohlgethan JR, Cathcart ES.
    Journal: J Immunol; 1981 Sep; 127(3):1003-7. PubMed ID: 7264297.
    Abstract:
    A/J mice are highly resistant to induction of amyloidosis with serial injections of azocasein, compared to the CBA/J strain. (CBA X A) F2 hybrid mice were treated with azocasein, after spleen biopsy for assay of 3 immunologic functions differing in the parent strains. The proportions of amyloid susceptibility and resistance in the hybrid population conformed to the expectations for a single gene. Low responses to the T cell mitogen concanavalin A correlated with resistance to amyloid induction, whereas the response to lipopolysaccharide and the level of natural killer activity were independent of susceptibility to amyloidosis.
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