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  • Title: Genetic control of antisperm autoantibody response in vasectomized guinea pigs.
    Author: Tung KS, Teuscher C, Goldberg EH, Wild G.
    Journal: J Immunol; 1981 Sep; 127(3):835-9. PubMed ID: 7264305.
    Abstract:
    About 50% of vasectomized and none of sham-operated outbred Hartley GP develop autoantibodies to TSDA, surface antigens on sperm, spermatids, and residual bodies detectable by a sensitive quantitative cellular radioimmunobinding assay. A similar study of anti-TSDA antibody responses on different strains of GP demonstrates that Strain 13 GP are high responders and PLLhr guinea pigs are nonresponders, whereas the responses of Strain 2 and PLLlr GP are intermediate. Furthermore, 100% of vasectomized F1 GP between Strain 13 females and PLLhr males produce anti-TSDA antibody. Of the vasectomized back-cross GP between the F1 and PLLhr, 46% produce anti-TSDA antibody, 54% do not. These data provide strong evidence that autoimmune antibody response to sperm surface antigens in vasectomized GP is controlled by a single dominant autosomal or X-linked gene. Antisera from vasectomized Strain 13, F1, and back-cross GP are found to react with 3 major polypeptides (MW 63, 37, and 22 kd) on sperm surface that can be radioiodinated and extracted by NP-40.
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