These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Potential anticonvulsants. 1. 5-Benzylhydantoins.
    Author: Mehta NB, Diuguid CA, Soroko FE.
    Journal: J Med Chem; 1981 Apr; 24(4):465-8. PubMed ID: 7265133.
    Abstract:
    A selected group of alkoxy- and halogen-substituted 5-benzylidino- and 5-benzylhydantoins was prepared and screened for anticonvulsant activity as measured by the ability of the compound to prevent maximal electroshock and metrazol-induced threshold clonic seizures in rats. The structure-activity studies revealed 5-[3-(trifluoromethyl)benzyl]hydantoin (14) to be the most potent member of the series.
    [Abstract] [Full Text] [Related] [New Search]