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  • Title: Plasma haemoglobin and complement activation in sickle cell disease.
    Author: DeCeulaer K, Wilson WA, Morgan AG, Serjeant GR.
    Journal: J Clin Lab Immunol; 1981 Jul; 6(1):57-60. PubMed ID: 7265176.
    Abstract:
    The role of haemolysis in producing deficient complement function in homozygous sickle cell disease was studied by measuring indices of complement activation and of haemolysis in 30 asymptomatic patients. Plasma concentration of C3d (an index of increased C3 turnover) was elevated in 40% of patients, and modest decreases in serum concentration of C3 and functionally (haemolytically) active factor B were found. There was a positive correlation between C3d and plasma haemoglobin concentration (r = 0.56, p less than 0.005). Reticulocyte count and foetal haemoglobin concentration also contributed to variation in C3d, though to a lesser extent than plasma haemoglobin. Intravascular haemolysis in sickle cell disease may produce activation of complement and thus cause partial depletion of functional factor B and C3. This may reduce the immune function of the alternative pathway.
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