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  • Title: Schultz-Dale reaction in mouse trachea.
    Author: Koppel GA, Haisch KD, Spaethe SM, Schmidtke JR, Fleisch JH.
    Journal: J Pharmacol Methods; 1981 Aug; 6(1):39-43. PubMed ID: 7265992.
    Abstract:
    A method was developed to induce contraction of immunologically sensitized mouse trachea by antigen (Schultz-Dale reaction). The response was mediated by immunoglobulin (Ig) E antibody directed against either the hapten DNP, the hapten carrier conjugate DNP-keyhole limpet hemocyanin (KLH), or the unmodified carrier KLH. Tracheal contractions were elicited by DNP-KLH, KLH, or DNP-bovine serum albumin (BSA) but not by DNP or BSA alone. This procedure represents a useful index of in vitro anaphylaxis in mouse airway smooth muscle.
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