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  • Title: [Effect of partial ileal bypass on the liver lipid level in dogs on an atherogenic diet].
    Author: Michalak J, Misiuna P, Kadziołka A, Ruciński T.
    Journal: Pol Arch Weter; 1980; 22(3):409-18. PubMed ID: 7267395.
    Abstract:
    An attempt was undertaken to find out to what extent a partial ileal bypass in healthy dogs fed for 6 and 12 months on overloaded atherogenic diet with an addition of metizol influences the level of lipids and the development of atherosclerosis of the aorta. For the investigations 16 mongrels, both sexes, from 2 to 5 years old were used. an unoperated, control group consisted of 6 dogs, which were fed on the atherogenic diet for 12 months. The dogs underwent a partial ileal bypass operation after Buchwald and Varco's method. When the dogs had recovered, 5 of them were on the atherogenic diet for 6 months, and 5 others for 12 months. After this period the animals were put to sleep. The isolated aorta was examined macro and microscopically. A segment of the right lobus of the liver was homogenized and from lg of a wet mass the lipids were extracted after the method of Folch et al. The level of lipids was estimated by thin-layer chromatography. The spots of the chromatograms were densitometrically analyzed and the results were statistically evaluated. In the control group the level of hepatic lipids in most components increased considerably. In the operated dogs and those fed for a long time, the level of these compounds decreased distinctly, especially in comparison with the control group, and was statistically highly significant in 1,3 - DG, TG and CE. The occurrence of statistically significant differences among the animals fed on the atherogenic diet for 6 and 12 months was not noticed. In dogs of both these groups other arteriosclerotic changes in the aorta were not demonstrated. During the experiment the animals felt well and their body weight did not change. No negative influence of the operation connected with the overloaded feeding of the level of hepatic lipids was observed. In both groups the above-mentioned level was near its norm.
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