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  • Title: Chelation in metal intoxication XI: effect of thiol chelators on lead poisoned rabbits.
    Author: Tandon SK, Behari JR, Singh S.
    Journal: Res Commun Chem Pathol Pharmacol; 1981 Jun; 32(3):557-60. PubMed ID: 7268200.
    Abstract:
    Potentials of 2,3 Dimercapto succinic acid (DMS) and D-Penicillamine, the currently acclaimed heavy metal chelating drugs, to enhance urinary excretion of lead and restore altered levels of urinary delta-amino-levulinic acid (delta-ALA) and blood lead, -zinc-protoporphyrin (ZPP) -delta-aminolevulinic acid dehydratase (delta-ALA-D) in lead poisoned rabbits, were compared. The better performance of DMS than D-Penicillamine has been attributed to two -SH groups as a stronger metal binding site in DMS molecule.
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