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  • Title: Arrhythmias during halothane anesthesia. III. The influence of barbiturates.
    Author: Andersen JR, Eikard B.
    Journal: Acta Anaesthesiol Scand; 1978; 22(4):430-6. PubMed ID: 726859.
    Abstract:
    The effect of barbiturates on cardiac rate and rhythm during halothane anesthesia without intubation was studied in a triple-blind, randomized trial with 28 patients. The test group was premedicated with pentobarbital and induced with thiopental, while the control group was anesthetized with halothane and nitrous oxide only. There was a significant preponderance of sinus-bradycardia and supraventricular disturbances in the control group. It is concluded that the use of barbiturates is advantageous because of their ability to suppress enhanced vagal tone.
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