These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Heterologous passive cutaneous anaphylaxis with bovine immunoglobulin E.
    Author: Gershwin LJ.
    Journal: Am J Vet Res; 1981 Jul; 42(7):1184-7. PubMed ID: 7271040.
    Abstract:
    Immunoglobulin (Ig) E was detected in sera of cows previously inoculated with ovalbumin in alum or in Freund's incomplete adjuvant. Titers greater than 64 were produced by homologous passive cutaneous anaphylaxis (PCA) reactions on calf skin, using sera from these cows. This bovine IgE was heat labile. Bovine sera containing IgE were used to examine cross-species reactivity by heterologous PCA. Rats, rabbits, guinea pigs, and dogs failed to develop PCA reactions when sensitized by intradermal injections of the bovine IgE and challenge exposed at intervals from 2 to 72 hours later with IV ovalbumin and Evan's blue dye. In contrast, sheep and goats became passively sensitized by the bovine IgE. Considerable variation in latent period and titer was apparent after comparison of results in heterologous species with each other and with the homologous recipient. Nonetheless, the ability of this homocytotropic antibody to cross species is important to the phylogenetic relationship of IgE in different species.
    [Abstract] [Full Text] [Related] [New Search]